This short call sets off a chain reaction of events.

Laura's death sets off a chain reaction of events around town.

His plans will set off a chain reaction of practical problems.

They didn't know for sure if they'd set off a chain reaction of all.

Even a small rate increase at the wrong time could set off a chain reaction that we would regret deeply.

"Its development would set off a chain reaction through the entire world economy."

The collapse of the market has set off a chain reaction that is felt throughout the region.

And tomorrow he would set off a chain reaction in the system.

In doing so he set off a chain reaction of panic.

These two events set off a chain reaction that leads the series through its first season.