inducibility

The immune system is a remarkably effective structure that incorporates specificity, inducibility and adaptation.

Immunizations are successful because they utilize the immune system's natural specificity as well as its inducibility.

The inducibility of many of these genes is known to be due to transcriptional activation of their promoters.

The fourth lac gene is lacI, encoding the lactose repressor-"I" stands for inducibility.

Furthermore, it was also shown that a further deletion of 260 bp almost completely abolishes both basal level transcription and inducibility by retinoic acid (15).

This deliberate induction of an immune response is successful because it exploits the natural specificity of the immune system, as well as its inducibility.

A second enzyme, IDO, is distinguished from TDO by its expression pattern, substrate specificity and inducibility.

Inducibility by interferon-alpha/beta, but not by interferon-gamma, is mediated by an interferon-stimulated response element in the promoter region [ 27 ] .

Both Cripps and Denniss have found a strong correlation between late potentials and the inducibility of ventricular arrhythmias at programmed ventricular stimulation.

There also appears to be a strong correlation between depressed BRS and the inducibility of sustained monomorphic ventricular tachycardia at programmed ventricular stimulation.

A unique feature of the hsromega gene, which led to discovery of the 93D puff in 1970, is its singular inducibility with benzamide and a variety of other amides.

Given the role that MHCII may play in tumor immunity, further attempts to restore inducibility in IFNg-resistant tumors appear to be warranted.

PMA did not improve IFNg inducibility of MHCII in MSTO-211H and HepG2 cell lines (data not shown).

High risk features that may be present during PES include an effective refractory period of the accessory pathway less than 270 ms, multiple pathways, septal location of pathway, and inducibility of supraventricular tachycardia.

Therefore, we wished to determine whether the poor IFNg inducibility of MHCII in LS1034, MSTO-211H and HepG2 cell lines could be explained by the loss of Rb.

Ohyama K, Akaike T, Hirobe C, Yamakawa T. Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth.

When using the Tet system in cell culture, it is important to confirm that each batch of fetal bovine serum is tested to confirm that contaminating tetracyclines are absent or are too low to interfere with inducibility.

Discussion The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.

Dexamethasone-inducible expression of GFP fusion protein Western blot analysis with anti-GFP polyclonal antibodies (Clonetech) was used to test inducibility of GFP-LacI/NLS in transgenic plants.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Most frequently, poor MHCII inducibility in response to IFNg has been attributed to alterations in the IFNg signalling pathway and epigenetic silencing of gene expression (reviewed in Ref [ 13 ] ).

This possibility appears particularly important since the specific lack of CIITA inducibility was cited as the most common basis for lack of IFNg-induced MHCII expression among Rb-positive human tumor lines [ 13 21 ] .

The relevance of this mechanism to MHCII inducibility was recently supported by the evidence that PMA is able to enhance IFNg-dependent MHCII expression in THP-1 human leukemia cells through the up-regulation of IFNg receptors [ 19 ] .