Calluses also can be caused by improperly fitting shoes or by a skin abnormality.

A skin biopsy can be performed to determine if a skin abnormality is skin cancer or not.

This disorder is characterized by skin abnormalities that develop into streaks or lines of tumor-like lumps on various parts of the body.

In addition, distinctive skin abnormalities are often present.

A combination of symptoms may include seizures, developmental delay, behavioral problems, skin abnormalities, lung and kidney disease.

The most common skin abnormalities include:

Vesicles or other skin abnormalities may not be noticed until several years after birth.

Other results are progressive neurological deterioration, skin abnormalities, growth retardation, skeletal disease, and coarsening of facial features.

He started with the external exam, indicating skin abnormalities he thought could have been insect bites.

Some never develop the classic skin abnormalities that coined the name of the disease.