It was only the seventh time that a 15th seed has defeated a 2nd seed, and the second-highest margin of victory for one.
It marked the first time a No. 8 seed defeated a No. 1 seed in a seven-game series.
Top seed and World No. 1 Caroline Wozniacki defeated Vesnina 6-2, 6-3 in the final.
The fourth seed defeated Holland's Jacco Eltingh 7-6 (7/5), 6-3.
It was only the sixth time in NCAA Tournament history that a 15 seed defeated a 2 seed.
Six 13 seeds have defeated 4 seeds in the first round.
Both 12 seeds to win at this stage of the women's tournament defeated 4 seeds.
It was only the fifth time that a 15th seed has defeated a 2nd seed.
It was the fifth time in NBA history that an eighth seed defeated a first seed in a playoff series.
The No. 23 seed defeated Italy's Filippo Volandri to open the tournament.