Operating with Saratoga, she provided cover for the landings on Guadalcanal and Tulagi, 7 August 1942.
Ramsey's force was intended to provide distant cover for the impending landings on New Georgia and to prevent intervention by any Japanese carriers.
In April of that year, VMF-113 was tasked with providing air support for the landings at Ujelang.
Part of Hewitt's command was Force V which included five aircraft carriers to provide air cover for the landings.
In April of that year they were tasked with providing air support for the landings at Ujeland.
On 15 September, Manchester provided fire support for the landings at Inchon.
She provided screen and fire support for the amphibious landings of 15 June 1944.
Between 10 February and 9 March, she screened escort carriers as they provided air cover for the landings on Iwo Jima.
She provided direct and indirect air support for the amphibious landings.
On 8 September, she anchored at Jinsen, Korea, whence she provided air support for the landings of the occupation force.