The largest modern study with an intent-to-treat prospective design was published in 1998 by a team from the Johns Hopkins Hospital and followed-up by a report published in 2001.

The first randomised controlled trial was published in 2008, which had an intent-to-treat prospective design, but no blinding.

The prospective design and the large number of cases give the study strength, but there was no data on health behaviors, quality of health care or other risk factors that could affect the conclusions.

This prospective design and long follow-up are major strengths of the study.

Clearly, for the purpose of comparing prevalence among diverse populations, a prospective design is strongly advantageous, but likely not congruent with the goals of clinical practice.

First, the prospective design made for high-quality data and minimised biases in ascertainment or classification.

Artists from around the country are expected to submit prospective designs for the project as part of an $80,000 national competition sponsored by the Indiana Pacers.

It can entail prospective and retrospective designs and it permits synthesis of many individual case studies undertaken at different times and in different sites.

The authors write that their analysis benefits from its strong prospective design in which cases and transmission routes were detected with laboratory analysis.

In this stage content is developed as per the design prospective and in accordance with planning of the documents at previous stages.