SHM results in approximately one nucleotide change per variable gene, per cell division.
The number of single nucleotide changes on each branch of the phylogenetic tree is shown at the end of the row.
We can use site-directed mutagenesis to correct clones that carry single nucleotide changes or other small, localized defects.
We also examined the minimum number of nucleotide changes required for sites where only the nematode sequence varied (Fig 4B).
SFTPA1 variants result from nucleotide changes in the codons of amino acids 19, 50, 62, 133, and 219.
These hypertensive strains also shared uniquely 4 other nucleotide changes not present in the other strains (Table 5).
Furthermore, a single nucleotide change in the gene was found to be present in 83% of family members with Asperger's syndrome.
Genetic variation among humans occurs on many scales, from gross alterations in the human karyotype to single nucleotide changes.
As noted above, there are many different kinds of DNA sequence variation, ranging from complete extra or missing chromosomes down to single nucleotide changes.
This nucleotide change leads to substitution of methionine for threonine at position 790 (T790M).