In old age several major losses may occur within a short space of time.

The major loss seemed to be one of the men.

"And we still use these, for patients with major loss."

"His death represents a major loss for the medical community."

Had several major losses in a short period of time.

They'd feel a sense of major loss if they had to throw this stuff away.

For a man who was a star in Japan, this could be a major loss of face.

This process has caused a major loss of land on the island.

Not that he could fault himself for his one major loss.

Older adults often have many major losses within a short period of time.