Sometimes small changes can have a major impact on the way the business works.

It also has major impact on lost time at work.

This has had a major impact on education in the 21st century.

But if I could, it would have a major impact.

In only one game, his second, did he make any major impact.

Recent events have had a major environmental impact on the city.

It will have a major impact on many areas of business life.

But the potential for a major economic impact is already clear.

The relationship would have a major impact on his future career.

The decision cut 1,800 jobs and is expected to have a major impact on the local economy.