She looked at me with great sadness in her eyes.

This day has brought terrible news and great sadness to our country.

She would have to overcome a great sadness in her life, I could see.

It is a great sadness to me, even today, that this was not possible.

The effect produced upon him was one of great sadness.

I feel great sadness that he is no longer with us.

When he spoke, there was great sadness in his words.

I also felt great sadness for what this part of the world once was, and had become.

We wish your family and friends peace at this time of great sadness.

It is of great sadness to me that now they will never be joined.