elongator

The Elongator Protein Complex (ELP) is what regulates the growth of cortical projection neurons.

This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation.

Elongator Protein Complex 4 (ELP4) has been identified as a key component in the transcription of genes known to regulate the actin cytoskeleton, cell motility and migration of neurons.

It has been found that children with Rolandic epilepsy have a mutation of gene coding for the Elongator Protein Complex 4, which is involved in transcription and tRNA modification.

The gene for the elongator (internal) methionine transfer RNA in the archaebacterium Halobacterium volcanii contains a 75 base pair intron (intervening sequence) and lacks the 3′-terminal CCA sequence of the mature tRNA.

These modifications result in heavily phosphorylated RNAPII (RNAPIIo), the recruitment of the Elongator, which contains splicing and polyadenylation machineries, and the conversions of DSIF and NELF into elongation factors.