Leaf-extracts of Hydrangea macrophylla are being investigated as a possible source of new chemical compounds with antimalarial activity.

Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity.

A 1998 article reported that naphthoquinones originating from N. thorelii showed antimalarial activity.

It exhibits potent antimalarial activity even against a drug-resistant strain.

Roxithromycin has also been tested to possess antimalarial activity.

In addition, bafilomycin A1 has antimalarial activity It has been shown to decrease multi-drug resistance.

Laboratory studies have confirmed that species related to bitter melon have antimalarial activity, though human studies have not yet been published.

Arterolane, also known as OZ277 or RBx 11160, is a substance being tested for antimalarial activity by Ranbaxy Laboratories.

There is some evidence for antimalarial activity for doxorubicin and similar compounds.

The rhizome has been shown to have weak antimalarial activity in mice.