An even older saying, dating back to the dawn of history, states that those whom the gods wish to destroy they first make mad.

It has been said, that those the gods would destroy they first make mad.

Made mad with the pain, the Slaughterer awoke, as it were.

He also showed us that it was possible not to care about whom you made mad along the way.

Yes, Tur would be made mad if the prisoner escaped.

They were four men, but, made mad by the sight, Mavovo turned on them and killed them all.

Whom the gods would destroy, they first make mad; that was part of Garth's story, too.

Either way, they'll come here, made mad by victory or by defeat, it doesn't matter which.

Those whom the gods would destroy, they first make mad.

And of course, the physical change makes most quite mad.