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Then, any necrotic tissue debris in the ulcer bed must be removed so that healthy new cells are able to migrate into the damaged area and proliferate.
The abdomen was opened and the stomach was exposed to assess the mucosal blood flow at the ulcer margin, ulcer bed, and adjacent intact mucosa.
Terminal Interruption of Reflux Source Technique entails blocking off the veins that drain the ulcer bed using Sotradecol or Polidocanol foam, administered by ultrasound guidance.
The mechanism of the healing is unknown but previous studies showed that the new vacularisation at the ulcer margin, the establishment of adequate blood flow around the ulcer base, and stimulation of cell migration and proliferation in the granulation tissue at the ulcer bed are the key factors in this process.