thrombopoietin

But there was no obvious place where thrombopoietin should be made.

There were probably six or eight teams going after thrombopoietin, he said, from companies and academic laboratories.

Maybe, they thought, this was a receptor for the mysterious thrombopoietin.

The liver is a major site of thrombopoietin production.

One mouse cell lived and it was making thrombopoietin.

Two of them are currently in clinical use: interleukin 11 and thrombopoietin.

Thrombopoietin was cloned by five independent groups in 1994.

Then the researchers mutated the mouse cells, trying to turn on the gene that makes thrombopoietin.

Therefore, the rising and dropping platelet concentrations regulate the thrombopoietin levels.

The pigs began making thrombopoietin to replenish their platelets.

Thrombopoietin shows great promise for preventing platelet depletion during chemotherapy.

The investigators also asked which cells in the body make thrombopoietin, Dr. Foster said.

Despite numerous trials, thrombopoietin is not used therapeutically.

Thrombopoietin plays a role in inducing the megakaryocyte to form small proto-platelet processes.

To re-form platelets, the pigs made thrombopoietin and the hormone circulated in their blood.

Thrombopoietin is one of the Class I hematopoietic cytokines.

Then they could clone the gene, put it in cells and force the cells to churn out thrombopoietin.

The primary signal for megakaryocyte production is thrombopoietin or TPO.

Thrombopoietin is a glycoprotein hormone that regulates the production of platelets by the bone marrow.

However, physiologically, the liver and the bone marrow stromal cells are the primary sites of thrombopoietin production.

CSFs and thrombopoietin also improve the outcome of patients who receive bone marrow transplants.

Thrombopoietin stimulates megakaryopoiesis, process of megakaryocyte maturation and differentiation.

Methods for stimulating granulocyte-macrophage lineage using thrombopoietin.

Thrombocytopenia - due to both congestive splenomegaly as well as decreased thrombopoietin from the liver.

Thrombopoietin, upon release, binds to its receptor, c-mpl, found on megakaryocyte progenitor cells.