tachyphylaxis

Significant tachyphylaxis can occur by day 4 of therapy.

Polymorphisms of the beta-2 receptor play a role in tachyphylaxis.

Tachyphylaxis: The acute development of tolerance to the action of a drug after repeated doses.

Nicotine may also show tachyphylaxis over the course of a day, although the mechanism of this action is unclear.

Hydralazine displays tachyphylaxis if given as a monotherapy for antihypertensive treatment.

Tapering the dose or increasing it a bit seems to help, but tachyphylaxis does occur again rapidly in those individuals affected.

A rapid drug tolerance is termed tachyphylaxis.

Also termed tachyphylaxis, downregulation, fade or drug tolerance.

With prolonged use, tolerance and tachyphylaxis can occur and the elimination half-life may increase, up to days.

To prevent tachyphylaxis, a topical steroid is often prescribed to be used on a week on, week off routine.

Psychedelics such as LSD-25 and psilocybin-containing mushrooms demonstrate very rapid tachyphylaxis.

"Tachyphylaxis and phosphodiesterase type 5 inhibitors".

Unfortunately, tachyphylaxis commonly occurs.

Dobutamine, a direct-acting beta agonist used in congestive heart failure, also demonstrates tachyphylaxis.

In addition to post-treatment relapse, depressive symptoms can even recur in the course of long-term therapy (tachyphylaxis).

Topical nasal or ophthalmic decongestants quickly develop tachyphylaxis (a rapid decrease in the response to a drug after repeated doses over a short period of time).

SSRIs or Tricyclic antidepressants demonstrate tachyphylaxis after some weeks of prolonged therapy in some certain individuals.

Benzodiazepines like Diazepam, Alprazolam and Nitrazepam etc. demonstrates tachyphylaxis in certain individuals after a certain time.

Repeated application can result in tachyphylaxis (reduced effectiveness) due to the formation of anti-mouse antibodies in the patient, which accelerates elimination of the drug.

Repeated doses of ephedrine may display tachyphylaxis, since it is an indirectly acting sympathomimetic amine, which will deplete noradrenaline from the nerve terminal.

Short-term tolerance can be caused by depleted levels of neurotransmitters within the synaptic vesicles available for release into the synaptic cleft following subsequent reuse (tachyphylaxis).

As with other G protein-coupled receptors, signalling by the mu opioid receptor is terminated through several different mechanisms, which are upregulated with chronic use, leading to rapid tachyphylaxis.

Some people are able to 'trip' by taking up to three times the dosage, yet some users may not be able to negate tachyphylaxis at all until a period of days has gone by.

Use of intranasal decongestants (such as oxymetazoline) for more than three days leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenoceptor mediated down-regulation and desensitization of response.

Subsequent studies have revealed that VEGF-A administration causes greater vasodilatation of coronary vessels than serotonin or nitroglycerin, and also causes tachyphylaxis via a nitric oxide-dependent mechanism [ 39].