somatodendritic

The 5-HT receptors in the raphe nucleus are largely somatodendritic autoreceptors, whereas those in other areas such as the hippocampus are postsynaptic receptors.

Those located on the soma and dendrites are called somatodendritic, and those located presynaptically in the synapse are aptly titled presynaptic.

Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT receptors.

Initial studies reported that the sorting of isoforms changed through development, where Tropomyosin 4 was initially localized to the growth cone of growing neurons but in mature neurons it was relocated to the somatodendritic compartment.

By antagonizing the somatodendritic and presynaptic α-adrenergic receptors which function predominantly as inhibitory autoreceptors and heteroreceptors, mianserin disinhibits the release of norepinephrine, dopamine, serotonin, and acetylcholine in various areas of the brain and body.