sharpless oxyamination

Osmium(VIII) oxide is also used in catalytic amount in the Sharpless oxyamination to give vicinal amino-alcohols.

The Sharpless oxyamination (often known as Sharpless aminohydroxylation) is the chemical reaction of alkenes with alkyl imido osmium compounds to form vicinal amino-alcohols.

Karl Barry Sharpless and group discover a stereoselective oxidation reactions including Sharpless epoxidation, Sharpless asymmetric dihydroxylation, and Sharpless oxyamination.

Sharpless complemented these reduction reactions by developing a range of asymmetric oxidations (Sharpless epoxidation, Sharpless asymmetric dihydroxylation, Sharpless oxyamination) during the 1970's to 1980's.

In 2001 he won a half-share of the Nobel Prize in Chemistry for his work on stereoselective oxidation reactions (Sharpless epoxidation, Sharpless asymmetric dihydroxylation, Sharpless oxyamination).