primary cilium

Only recently has great progress been made in understanding the function of the primary cilium.

The primary cilium is now known to play an important role in the function of many human organs.

Although the primary cilium was discovered in 1898, it was largely ignored for a century.

"Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.

The protein encoded by this gene localizes to the primary cilium and to the plasma membrane.

Its function appears two be twofold: CEP164 is required for primary cilium formation.

Its intracellular localzation is the primary cilium, a small organelle involved in signal transduction.

The gene functions in centriole migration to the apical membrane and formation of the primary cilium.

Until the 1990s, the prevailing view of the primary cilium was that it was merely a vestigial organelle without important function.

The BBSome is a component of the basal body and is involved in formation of the primary cilium.

More recent studies have hypothesized that chondrocyte primary cilium act as a mechanoreceptor for the cell, transducing forces from the extracellular matrix into the cell.

Non-motile (or primary) cilia usually occur one per cell; nearly all mammalian cells have a single non-motile primary cilium.

In addition, a defect of the primary cilium in the renal tube cells can lead to polycystic kidney disease (PKD).

His research team at Imagine focuses on forms of neurocristopathy and fetal syndromes that result from abnormal development of primary cilium and planar polarity.

The "primary cilium was long considered--with few exceptions--to be a largely useless evolutionary vestige, a vestigial organelle.

Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium.

Their research leads them to conclude "Our findings suggest that the NPHP genes (NPHP1, NPHP3, NPHP4) involved in the pathogenesis of recessive cystic kidney disease also belong to a common pathway in the primary cilium of kidney cells."