picrotoxin

The picrotoxin it contains can cause death, even in small amounts.

Picrotoxin used to be used to paralyze fish in the fishing industry.

Its effect is similar to picrotoxin, another cage convulsant.

However, picrotoxin, the active chemical in levant berry, is still used in research.

Jungle tribes apply picrotoxin taken from the seeds to arrow tips for hunting.

However, over time, the narrow therapeutic window associated with picrotoxin administration-which can also induce seizures-resulted in its disuse.

Picrotoxin that is taken from levant berry seeds is used for epilepsy, night sweats, and as a stimulant.

Its fruit, Cocculus indicus, is the source of picrotoxin, a poisonous alkaloid with stimulant properties.

A mnemonic drug-" "Am I getting picrotoxin or one of the pentylenctetrazol derivatives?"

As such, picrotoxin can be used to counter barbiturate poisoning, that can occur during general anesthesia or during a large intake outside of the hospital.

Picrotoxin is classified as an illegal performance-enhancing "Class 1 substance" by the American Quarterhorse Association.

These oscillations can be disrupted by GABA blocker picrotoxin.

Picrotoxin blocks presynaptic inhibition, and some of the others block postsynaptic inhibition, but pentylenetetrazol doesn't interfere with either.

The seeds deliver picrotoxin, a sesquiterpene, while the seed shells contain the tertiary alkaloids menispermine and paramenispermine.

As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has stimulant and convulsant effects.

They found that dilute intravenous solutions of picrotoxin (cocculin)-- a neurostimulatory plant product-were effective as an antidote in that setting.

These allosteric sites are the targets of various other drugs, including the benzodiazepines, nonbenzodiazepines, barbiturates, ethanol, neuroactive steroids, inhaled anaesthetics, and picrotoxin, among others.

Schizophrenia - schizophrenic convulsions are relieved by picrotoxin from the Levan berry of S. and S. E. Asia.

However, investigators were unable to find an increase in glutamate during seizures induced by systemic kainate, bicuculline, picrotoxin, locally-applied bicuculline, or quinolinic acid.

Antagonists/Negative allosteric modulators: bicuculline, cicutoxin, flumazenil, furosemide, gabazine, oenanthotoxin, picrotoxin, Ro15-4513, thujone.

Ionotropic GABA receptors are used in binding for various drugs such as barbiturates (Phenobarbital, pentobarbital), steroids, and picrotoxin.

In functional expression studies, TAS2R14 responds to (-)-α-thujone, the primary neurotoxic agent in absinthe, and picrotoxin, a poison found in fishberries.

In another experiment, seizures were introduced in the feline brain model using local administration of picrotoxin adjacent to the electrode array on the frontal-medial area of the brain.

They found that in vivo convulsant potency was strongly correlated to in vitro affinity to the picrotoxin binding site on the GABA-A receptor complex.

It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel.