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The price of the compound increased, affecting the cost of diagnostic histopathology, and prompted a search for alternative nuclear stains.
Lillie RD, Pizzolato P, Donaldson PT (1976) Nuclear stains with soluble metachrome mordant lake dyes.
Morphologically, cells dying of PCD appear atrophic and exhibit condensed nuclei, which can be stained with nuclear stains (bisbenzimide or propidium iodide), or by the TUNEL assay.