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Like morphine-N-oxide, it was studied as a potential pharmaceutical drug and is considerably weaker than codeine.
Morphine-N-oxide (genomorphine) is an active opioid metabolite of morphine.
Morphine-N-oxide (genomorphine)
A possible explanation is that morphine-N-oxide is rapidly inactivated in the liver and impairment of inactivation processes or enzymes increases functionality.
However, pretreatment with amiphenazole or tacrine increases the potency of morphine-N-oxide in relation to morphine (intraperitoneally more so than in subcutaneous administration).