molecular disease

This discovery of what Pauling came to call a "molecular disease" was revolutionary.

Sickle cell anemia: a potential nutritional approach for a molecular disease.

Better understanding this may lead to therapies for molecular diseases caused by mis-organization of nuclear protein.

This was the first molecular disease characterized.

Its technology revolves around dynamically updated molecular disease models that form the basis of the expert systems.

Pauling also introduced the term "molecular disease", which, together with molecular medicine, has become widely used.

The molecular disease concept put forward in the 1949 paper also became the basis for Linus Pauling's view of evolution.

The paper introduced the concept of a "molecular disease", and is considered a major impetus to the development of molecular medicine.

Donald Fredrickson, then head of the Molecular Disease Branch, became aware of the case and had a hunch that the original diagnosis was incorrect.

Since the early 1990s, a new class of molecular disease has been characterized based upon the presence of unstable and abnormal expansions of DNA-triplets (trinucleotides).

His work in establishing the field of molecular biology; his studies of hemoglobin led to the classification of sickle cell anemia as a molecular disease."

"The probability is very high," said Dr. Bryan Brewer, chief of the molecular diseases branch at the National Heart, Lung and Blood Institute.

He also advocated eugenic policies, such as marking all who carry the sickle cell trait and other molecular disease genes, to reduce the number of children born with genetic diseases.

A major user of the technology is expected to be DNA testing laboratories, which hope to translate patient-specific genetic characterization to patient-specific clinical treatment advice for molecular diseases.

'And it is singular, very singular,' he added with a complacent smile, 'that the world should owe all its finest art and literature merely to a few varieties of molecular disease!'

In 1957, Zuckerkandl met renowned chemist Linus Pauling, who was becoming interested in molecular diseases and molecular evolution as an outgrowth of his activism on topics concerning nuclear power.

Dr. Bryan Brewer, chief of the molecular disease branch at the National Heart, Lung and Blood Institute, said, "No one has ever seen anything like this in this amount of time."

Among the cases that Dr. Zerhouni has condemned is that of Dr. Bryan Brewer Jr., chief of the National Heart, Lung and Blood Institute's molecular disease branch.

At Rutgers since 1974, he combines these fields by investigating protein-DNA, and drug-DNA interactions, particularly as they relate to regulation of gene expression, DNA damage repair, and molecular diseases.

In November 1949, Linus Pauling, Harvey Itano, S. J. Singer and Ibert Wells published "Sickle Cell Anemia, a Molecular Disease" in the journal Science.

Francis Crick acknowledged Pauling as the "father of molecular biology" His discovery of sickle cell anemia as a "molecular disease" opened the way toward examining genetically acquired mutations at a molecular level.

Ingram V.A. "Sickle-Cell Anemia Hemoglobin: The Molecular Biology of the First "Molecular Disease"-The Crucial Importance of Serendipity", Genetics, Vol.

In November 1949, with the seminal paper, "Sickle Cell Anemia, a Molecular Disease", in Science magazine, Linus Pauling, Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine.

This was the first time a genetic disease was linked to a mutation of a specific protein, a milestone in the history of molecular biology, and it was published in their paper "Sickle Cell Anemia, a Molecular Disease".

Pauling reinterpreted the large body of research on vitamin C based on comparative studies of the biochemical genetics of vitamin C synthesis in different species, as well his own theories about "molecular disease" and recent developments in molecular evolution.