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Studies where the chances of high benefit for subjects are low or where benefits are unlikely can cause misestimation.
Therapeutic misestimation may occur when subjects overestimate the benefits that a study can grant them or when they underestimate the potential risks associated with a particular study.
"I see the patterns of a clever operation, a coordinated operation, but one which has a fatal flaw, and that flaw is-a misestimation of the American President.
A perceived relationship between an independent variable and a dependent variable that has been misestimated due to the failure to account for a confounding factor is termed a spurious relationship, and the presence of misestimation for this reason is termed omitted-variable bias.
What separates therapeutic misconception from therapeutic misestimation is that in therapeutic misestimation subjects overestimate the benefits of a trial even though they properly understand how research procedures differ from the care they would otherwise receive in clinical practice settings.
