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They found a maximal dose of resveratrol increased the median lifespan by 56%.
"We felt it was important to use the maximal dose, based on laboratory studies," Dr. Salmon said.
It has been shown to decrease angina episodes in individuals with coronary artery disease on maximal doses of amlodipine.
The other indication for insulin is of course when glycaemic control is poor on a maximal dose of a sulphonylurea.
Such control permits a spider to administer either a dry bite, a dose appropriate to the nature of the prey or enemy, or a maximal dose.
The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses.
"Tanya, I need IV potassium fast, maximal dose, sixty milliequivalents in a liter, run it in at ten to twenty milliequivalents an hour."
A 24-hour exposure to IFN-γ was sufficient to potently and irreversibly inhibit osteoclastogenesis in the presence of maximal doses of RANKL (Fig.
Calculations of the γ radiation dose accumulated by the seeds since burial gave a reading of 0.07 k Gy, the highest maximal dose recorded for seeds that have remained viable.
Bayer CropScience results show that the maximal dose for which no effect was observed was 20 ppb, while the amount of residue in parts of the plant available to the insect (aerial parts) was below 1.5 ppb.
At maximal doses, and sometimes at much lower doses, side effects of iodide used for medical reasons, in doses of 1000 times the normal nutrional need, may include: acne, loss of appetite, or upset stomach (especially during the first several days, as the body adjusts to the medication).
The mean and maximal doses used for olanzapine were considerably higher than standard practice, and this has been postulated as a biasing factor that may explain olanzapine's superior efficacy over the other atypical antipsychotics studied, where doses were more in line with clinically relevant practices.
These results closely agree with a study of Stone and coworkers who, using cholesintigraphy, observed a 21% reduction of gall bladder emptying in response to a maximal dose of cholecystokinin 8 in diabetic patients with cardiovascular autonomic neuropathy in comparison with patients without cardiovascular autonomic neuropathy.