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About half of all Bernese mountain dogs are prone to an unusual blood cancer called malignant histiocytosis.
Langerhans cell sarcoma is a form of malignant histiocytosis.
Up to 25 percent of Bernese Mountain Dogs may develop malignant histiocytosis in their lifetime.
Histiocytosis (and malignant histiocytosis) are both important in veterinary as well as human pathology.
This latter form of HS is most like malignant histiocytosis (MH).
Malignant disorders include malignant histiocytosis (histiocytic sarcoma) and the monocytic or myelomonocytic leukemias.
Hemangiosarcoma, fibrosarcoma, osteosarcoma and malignant histiocytosis are particularly devastating, and occur at higher rates in Flat-coated Retrievers than in many other breeds.
Bernese Mountain Dogs are killed by a multitude of different types of cancer, including malignant histiocytosis, mast cell tumor, lymphosarcoma, fibrosarcoma, and osteosarcoma.
Several inherited medical issues that a Bernese Mountain Dog may face are malignant histiocytosis, hypomyelinogenesis, progressive retinal atrophy, and possibly cataracts and hypoadrenocorticism.
Other breeds with a possible genetic tendency toward malignant histiocytosis include Rottweilers, Flat-Coated Retrievers, and Golden Retrievers.
Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.
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