lymphokines

Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection.

Lymphokines aid B cells to produce antibodies.

Important lymphokines secreted by the T helper cell include:

At the same time, they carry receptors for lymphokines that allow them to be "activated" into single-minded pursuit of microbes and tumour cells.

At the site, the cells release signaling molecules called lymphokines to damp down reactive immune cells that normally cause inflammation.

The drug, which can be manufactured using genetically altered microorganisms, is of a class of natural substances produced by the immune system that are called lymphokines.

Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.

These cells release enzymes, lymphokines, cytokines, and growth factors that can act on parenchymal and mesenchymal cells.

In recent years scientists have discovered many substances, called lymphokines, that are produced by white blood cells and have multiple, only partially understood, effects in the human body.

Accordingly, lymphokines and monokines, which collectively came to be known as cytokines, became prime research subjects for those interested in lymphocyte activation [ 7 8 ] .

The cyclosporin A/cyclophilin complex inhibits the calcium- and calmodulin-dependent phosphatase, calcineurin, resulting in a failure to activate genes encoding interleukin-2 and other lymphokines.

The macrophages also carry receptors for lymphokines, and lymphoines act as cytokines which further attract T cells, B cells and natural killer cells.

Specific inhibition of mRNA accumulation for lymphokines in human T cell line Jurkat by mycobacterial lipoarabinomannan antigen.

These hormones, called lymphokines, make mischief in surrounding tissue and organs, causing swelling and fever. . . . The effect of superantigens is so murderously swift.

LAK cells respond to these lymphokines, particularly IL-2, by lysing tumor cells that were already known to be resistant to NK cell activity.

However, it can also be accomplished by the co-administration of plasmid DNA encoding immune regulatory molecules, i.e. cytokines, lymphokines or co-stimulatory molecules.

Approximately 25% of patients may have systemic symptoms such as fever, night sweats, and weight loss that are secondary to release of lymphokines and cytokines by R-S cells.

This combination of MHC and antigen attracts a matching helper T cell, which releases lymphokines and activates the B cell.

Center of Research The substances that have been the center of Kodak's research efforts are lymphokines, proteins and hormones that regulate the responses of the body's immune system.

When exposed to antigens, T-lymphocytes form clones of sensitized cells and produce destructive compounds like lymphokines that help in the attack against particular antigens and invading organisms in various complex ways.

Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response.

M1 macrophages, or classically activated macrophages, are immune effector cells that are aggressive against microbes and can engulf and digest affected cells much more readily, and they also produce many lymphokines.

Our data may, however, serve as a basis for further studies aiming at the identification of regulatory factors (for example, hormones, lymphokines, cytokines) that modulate the expression and function of integrins of colorectal cancer cells.

Transfer factors were originally described as immune molecules that are derived from blood or spleen cells that cause antigen-specific cell-mediated immunity, primarily delayed hypersensitivity and the production of lymphokines, as well as binding to the antigens themselves.

Rather, an altered cell-mediated immunologic response with abnormal secretion of lymphokines by T cells is thought to reduce the production of anions in the glomerular basement membrane, thereby increasing the glomerular permeability to serum albumin through a reduction of electrostatic repulsion.