long-term toxicity

The long-term toxicity of n-hexane in humans is well known.

Clinical trials are needed to establish the regimens with the best efficacy and least long-term toxicity.

Conventional long-term toxicity, reproduction, mutagenicity, and carcinogenicity studies have been performed in laboratory animals.

Concerns about bioengineered foods include possible allergic reactions, potential long-term toxicity and unforeseen effects of releasing novel organisms into the environment.

Follow-up of infants, both infected and uninfected, who are exposed to antiretroviral drugs is critical to identifying potential short- and long-term toxicities.

The theory is that consumption of the fruit bat transferred sufficient quantities of the toxin to lead to long-term toxicity, although this has not yet been proven.

Further follow-up will be needed to determine if long-term toxicities differ between those receiving three versus five cycles of ABVE-PC.

To compare Anthracycline-based chemotherapy regimens to a Docetaxel-Capecitabine regimen which may be associated with increased efficacy and reduced long-term toxicities for women with breast cancer.

These tests include: acute toxicity test (short-term toxicity test) and chronic toxicity test (long-term toxicity test).

The long-term toxicity and financial expense of HAART makes it undesirable as the standard, long-term treatment for HIV patients.

Some researchers say side effects occur more frequently than patients and even doctors realize, and they note that whether the drugs produce any long-term toxicity over 20 or 30 years remains unknown.

Toxic Chemicals: There are now more than 320 chemicals or chemical categories on this list, which were selected by Congress primarily because of their chronic or long-term toxicity.

The discovery of musk xylene residues in the environment prompted new concerns about its possible long-term toxicity, and led to the sharp decline in its use from the mid to late 1980s.

The long-term toxicity of copper has not been well studied in humans, but it is infrequent in normal populations that do not have a hereditary defect in copper homeostasis.

Quantum dots, with their photostability and bright emissions, have generated a great deal of interest; however, their size precludes efficient clearance from the circulatory and renal systems while exhibiting long-term toxicity.

The long-term toxicity of the drugs themselves - their impact on the liver, for example - could mean that patients might undergo a miraculous recovery at the start, only to die from the effects of treatment in later life.

Schellong G, Pötter R, Brämswig J, et al.: High cure rates and reduced long-term toxicity in pediatric Hodgkin's disease: the German-Austrian multicenter trial DAL-HD-90.

Added text to state that intensity-modulated radiation therapy may have less short- and long-term toxicity than conventional radiation therapy in terms of xerostomia, acute dysphagia, and skin fibrosis (cited Madani et al. as reference 7).

The protocol is designed to increase efficacy of treatment while shortening the duration of treatment for a subset of low-risk patients and reducing both acute toxicity (myelosuppression) and long-term toxicity (impaired fertility) from cyclophosphamide.

For those children with low-grade glioma for whom radiation therapy is indicated, conformal radiotherapy or stereotactic radiosurgery approaches appear effective and offer the potential for reducing the acute and long-term toxicities associated with this modality.

IF, Carpanini, FMB, Grasso, P and Lansdown, ABG, Long-term toxicity of propylene glycol in rats, Food and Cosmetics Toxicology, Apr.

The MHRA stated that its review "has identified that the manufacturer's biological safety assessment of this product in inadequate, due to the lack of long-term toxicity data or clinical follow-up, together with methodological flaws in some of the pre-clinical tests".

The paper published in September 2012 by Séralini and his colleagues was titled "Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize" and was published in the journal Food and Chemical Toxicology.

Children with supratentorial anaplastic ependymoma and children with infratentorial ependymoma who have a near total resection or better: These children receive conformal radiation therapy directed at the primary site to determine whether cure can be achieved with this approach while minimizing radiation-associated long-term toxicities.

While our data indicate that this TI strategy should not be pursued outside of a clinical trial setting, we argue that it will be important to collect additional data on the potential benefits of drug-sparing regimens (such as reduced long-term toxicity and reduced cost) and to define long-term outcomes in comparison with continuous therapy.