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Both the kappa and the lambda chains can increase proportionately, maintaining a normal ratio.
Ig lambda chain C regions is a protein that in humans is encoded by the IGLC2 gene.
Translation of the spliced mRNA for either the kappa or lambda chains results in formation of the Ig κ or Ig λ light chain protein.
Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the kappa type, in contrast to the usual concordance between a translocation involving chromosome 22 and lambda chain synthesis.