insulin-mediated

These data suggest that local uptake of D-glucose by insulin-sensitive tissues is an important determinant of insulin-mediated vasodilation.

Here we report such evidence - insulin-mediated MAP kinase regulation of 5-HT 2C receptor activity.

However, rapamycin abolished the insulin-mediated inhibition of SP-A gene expression in a dose-dependent manner.

In addition metformin may influence cancer cells through indirect (insulin-mediated) effects, or it may directly affect cell proliferation and apoptosis of cancer cells.

These findings raise concern about unwanted (potentially confounding) systemic haemodynamic effects of hand-warming on the measurement of insulin sensitivity and insulin-mediated vasodilation.

We found that central nesfatin-1 produced a pronounced increase in insulin-mediated phosphorylation of Akt in the liver of HFD-fed rats.

Insulin-mediated regulation also involves ERK, p38MAPK, and JNK signaling pathways.

However wortmannin, at concentrations of 5-200 nM, abolished the insulin-mediated inhibition of SP-A mRNA levels at all concentrations tested (5-200 nM, Fig.

Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis and inhibits insulin-mediated glycogenesis in muscle.

The pathogenesis of acanthosis nigricans is poorly understood, and likely to relate to an interplay of factors, including insulin-mediated activation of ILGF receptors on keratinocytes, and increased growth factor levels.

The major part of insulin-mediated glucose disposal takes place in the skeletal muscle, and increased amounts of intramyocellular lipid has been associated with insulin resistance and linked to decreased activity of mitochondrial oxidative phosphorylation.

Antioxidants may induce beneficial effects on diabetic complications by reducing blood pressure, attenuating oxidative stress and inflammatory biomarkers, improving lipid metabolism and insulin-mediated glucose disposal, as well as by enhancing endothelial function.

Since it is possible that the insulin-mediated stimulation of p44/42 MAPK phosphorylation had ended within a 15 min exposure to insulin, we performed additional experiments in order to evaluate the possibility of a shorter time course of insulin action.

Presently, we evaluated insulin-mediated vascular relaxation, assessed molecular markers of the insulin signaling pathway, and determined the involvement of ET-1 in response to insulin by using selective ETA- or ETB-receptor blockade in a lean model of type 2 diabetes.

A dysfunctional HPA-axis causes high cortisol levels to circulate, which results in raising glucose and insulin levels, which in turn cause insulin-mediated effects on adipose tissue, ultimately promoting visceral adiposity, insulin resistance, dyslipidemia and hypertension, with direct effects on the bone, causing "low turnover" osteoporosis.