indolent course

Although most infections follow an indolent course, the disease can progress rapidly.

It has an indolent course, some have survived for decades with multi-organ disease.

Some such cancers run indolent courses that wax and wane over years.

Occasionally, patients with locally advanced or metastatic disease may exhibit indolent courses lasting several years.

Typically, CBD has an insidious onset and runs an indolent course.

Classic Kaposi sarcoma (KS) usually is limited to the skin and has an indolent course.

MOE follows a much more chronic and indolent course than ordinary acute otitis externa.

Although ASPS displays a relatively indolent course, the ultimate prognosis is poor and is often characterized by late metastases.

Some patients have a prolonged indolent course, but others have disease that rapidly evolves into more aggressive types of NHL that require immediate treatment.

Classic KS most commonly runs a relatively benign, indolent course for 10 to 15 years or more, with slow enlargement of the original tumors and the gradual development of additional lesions.

Although the majority of cases follow an indolent course, some patients may have evidence of a blood disorder such as a myelodysplastic or myeloproliferative disorder at the time of diagnosis.

The advanced age of most of the patients, localized nature of the tumor, rarity of visceral involvement, and usually indolent course of the disease should temper the extent of the evaluation.

Franks LM, Bollen A, Seeger RC, et al.: Neuroblastoma in adults and adolescents: an indolent course with poor survival.

Given the indolent course of the disease in pediatric patients, it is reasonable to withhold extensive and mutilative surgeries and carefully observe children with locally recurrent or unresectable asymptomatic disease.

Few examples include: "Propionibacterium" sp., which are normal skin flora, have been responsible for infective endocarditis sometimes leading to deaths due to the indolent course of this abscess producing infection. "

Because M. ulcerans infection is associated with nonspecific clinical manifestations and indolent course, it is important to consider every nodule or ulcer in an endemic area as a suspected M. ulcerans infection until proven otherwise.

MTC associated with these mutations tends to follow a more indolent course and have a later age at onset, although there are several reports of individuals with ATA-level A mutations who developed MTC before age 20.