human prolactin

Purified human prolactin was scarce, heterogeneous, unstable, and difficult to characterize.

On the basis of these investigations 83/562 was established as the Second IS for human Prolactin.

Human prolactin receptors are insensitive to mouse prolactin.

Once stocks of these ampoules were depleted, 84/500 was established as the Third IS for human Prolactin.

Reference ampoules of IS 84/500 contain 2.5 g of lyophilized human prolactin, and have been assigned an activity of .053 International Units of prolactin.

Dr. Friesen was a recipient of the 1977 Canada Gairdner International Award "In recognition of his contributions to the understanding of the biochemistry, physiology and pathophysiology of lactogenic hormones and, in particular, for the identification of human prolactin."

The first International Reference Preparation (or IRP) of human Prolactin for Immunoassay was established in 1978 (75/504 1st IRP for human Prolactin) at a time when purified human prolactin was in short supply.