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Misincorporation may be especially pronounced under conditions of forced and massive gene overexpression.
The gene overexpression may play key roles in carcinogenesis.
Conditional gene overexpression mutations have several potential advantages for study of aging and life span.
By waiting until flies are young adults to activate gene overexpression, effects can be identified that are specific to adult aging.
RNAa has been used to study gene function in lieu of vector-based gene overexpression.
Results were reported recently for a screen for positive regulators of life span using a different P-element-based gene overexpression strategy [ 29].
The transcription of this promoter is activated upon feeding the fly doxycycline, leading to conditional gene overexpression and conditional mutations.
Biologic cellular characteristics of cancer, such as grade, hormone sensitivity, and gene overexpression are recognized as important predictors of cancer behaviors.
The biological corollaries of changes in gene expression profiles are noteworthy in that they may provide evidence on the molecular targets of Hox genes in cartilage, as well as on the consequences of Hox gene overexpression.
It is possible that in some of the lines the increase in life span between -DOX and +DOX is reduced because there is already some gene overexpression and life-span extension in the -DOX flies.
The system also provides powerful controls for genetic background effects, because control (no DOX) and over-expressing (+DOX) flies have identical genetic backgrounds and therefore any differences in life span must be due to DOX administration and gene overexpression.
Wörterbuch für Biologie