gene amplification

However, eventually this result was found to have been caused by selection for gene amplification and/or a higher mutation rate in cells unable to divide.

In squamous cell carcinoma, gene amplifications frequently target the 3q26.3 region.

They are a manifestation of gene amplification during the development of tumors, which give the cells selective advantages for growth and survival.

Typical epigenetic related events are: gene amplification and gene methylation.

Gene amplification may refer to:

The copy-making is known as gene amplification and it makes enough DNA available from the fragment being studied to permit analysis.

Gene amplification is responsible for overproduction of cyclin D protein in bladder cancer and esophageal carcinoma, among others.

Gene amplification appears to be in blocks of genes explaining the rapid and compact expansion of the cluster during the evolution of maize.

They have begun clinical trials for the treatment of advanced ovarian cancer through the use of a drug called hydroxyurea, which combats abnormal gene amplification.

Several mechanisms lead to the deregulated expression of cyclin E. In most cases, gene amplification causes the overexpression.

Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.

Overexpression can happen in one of three ways: as a result of gene amplification, impaired protein degradation, or chromosomal translocation.

Myc overexpression stimulates gene amplification, presumably through DNA over-replication.

The technician then applies a relatively new technology called gene amplification, which was developed elsewhere, to produce thousands of copies of the telltale fragment if it is present.

Gene duplication (or gene amplification) is any duplication of a region of DNA that contains a gene.

Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.

Clinical studies indicate that eIF4E gene amplification and protein overexpression is associated with malignant progression in these tumors [ 16 ] .

The first study to mention possible prognostic importance of HER-2 / neu gene amplification was reported in 1987 by Slamon et al .

Estrogen receptor and progesterone receptor status and HER2/neu gene amplification need to be reported as they may affect treatment options.

CISH methodology may be used to evaluate gene amplification, gene deletion, chromosome translocation, and chromosome number.

ALK inhibitors can also be used to treat another cause of neuroblastoma referred to as MYCN gene amplification.

Other examples include aberrant chromosomal fragments, such as double minute chromosomes, that can arise during artificial gene amplifications or in pathologic processes (e.g., cancer cell transformation).

A type of testing that identifies viral genes (e.g., specific sequences of nucleic acids) using gene amplification technologies such as polymerase chain reaction (PCR).

Another technique used to increase yields is gene amplification, where copies of genes coding for enzymes involved in the antibiotic production can be inserted back into a cell, via vectors such as plasmids.

Resistance can arise from DHFR gene amplification, mutations in DHFR, decrease in the uptake of the drugs, among others.