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However, if a sufficient quantity of uranium-235 could be isolated, it would allow for a fast neutron fission chain reaction.
The discovery that plutonium-239 could be produced in a nuclear reactor pointed towards another approach to a fast neutron fission bomb.
In some fast reactor designs, up to 20% of fissions can come from direct fast neutron fission of uranium-238, an isotope which is not fissile at all with thermal neutrons.