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Contributions from neighboring neurons may overlap, producing extracellular potentials of up to several millivolts.
With his student John Clark, he derived a mathematical relationship between the transmembrane potential and the extracellular potential produced by a propagating action potential in a nerve axon.
Another lab-on-a-chip similarly combined a microfluidic network in PDMS with planar microelectrodes, this time to measure extracellular potentials from single adult murine cardiomyocytes.