ethyl acetoacetate

Geuther is best known for his discovery of ethyl acetoacetate.

The preparation of ethyl acetoacetate is a classic laboratory procedure.

Reactions of ethyl acetoacetate with numerous other compounds were the main focus of his work there.

Ethyl acetoacetate can also be reduced to ethyl 3-hydroxybutyrate.

Methylthiouracil is prepared quite simply by condensation of ethyl acetoacetate with thiourea.

Aldol condensation of acetone and ethyl acetoacetate gave β-keto-ester 3.

Ethyl acetoacetate is subject to Keto-enol tautomerism.

Dane salt formation between 3,5-dimethoxyaniline and ethyl acetoacetate followed by borohydrate reduction gives synthon 1.

They directly form ethyl acetoacetate, and the yield is high when carried out under controlled circumstances; this method is therefore used industrially.

One synthesis involved protecting the primary amino group of ampicillin (1) as the enamine with ethyl acetoacetate (2).

The experimental work of his and others yielded puzzling results and induced debates on the nature of ethyl acetoacetate.

Similar to the behavior of acetylacetone, the enolate of ethyl acetoacetate can also serve as a bidentate ligand.

Two moles of ethyl acetate condense to form one mole each of ethyl acetoacetate and ethanol.

Acetoacetic acid can be prepared by the hydrolysis of the ethyl acetoacetate followed by acidification of the anion.

In collaboration with various other chemists, Knorr proved the concept that ethyl acetoacetate existed in a keto and an enol forms.

The organic compound ethyl acetoacetate (EAA) is the ethyl ester of acetoacetic acid.

Fructone is a ketal that is usually synthesized from ethyl acetoacetate and ethylene glycol in an acid catalyzed ketalization reaction.

The Claisen condensation - the simple method to make ethyl acetoacetate Diethyl malonate is made from acetic (ethanoic) acid in a series of simple steps.

Acid catalyzed condensation of 4 with ethyl acetoacetate then gives the fused tetrahydropyran derivative 5 (no doubt by a scheme quite analogous to prodolic acid).

Similar reactions with acetylacetone and ethyl acetoacetate proceed with loss of the acetyl group to give the β-substituted enamine. 1,1-Dipiperidinoethene and nitromethane give the β-nitroenamine.

The Biginelli reaction is a multiple-component chemical reaction that creates 3,4-dihydropyrimidin-2(1H)-ones 4 from ethyl acetoacetate 1, an aryl aldehyde (such as benzaldehyde 2), and urea 3.

Ethyl acetoacetate is often used in the acetoacetic ester synthesis similar to diethyl malonate in the malonic ester synthesis or the Knoevenagel condensation.

Modern practice is to add the oxime solution resulting from the nitrosation and the zinc dust gradually to a well-stirred solution of ethyl acetoacetate in glacial acetic acid.