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When disease processes disrupt these inhibitory pathways the reflex is "released" from its inhibitory shackles and elicitable once again, hence the term "frontal release sign".
I agree with these predictions in two respects: that the degree of life extension achieved by first-generation drugs of this sort may well approach the (currently unknown) amount elicitable by caloric restriction itself in humans, and that it is unlikely to be much exceeded by later drugs that work the same way.