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The nerve emerges at the mental foramen in the mandibula, and divides beneath the Depressor anguli oris muscle into three branches:
When the hypoplasia of the depressor anguli oris muscle is associated with congenital cardiac defects, the term 'Cayler cardiofacial syndrome' is used.
Half of the lower lip cannot be drawn down and outward because of the incomplete development (hypoplasia) or absence (agenesis) of the depressor anguli oris muscle.
The transversus menti, or transverse muscle of the chin, is a facial muscle that is often considered to be the superficial fibers of the depressor anguli oris muscle which cross to the other side of the face.