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Even with this defibrination, however, clinically significant bleeding is uncommon.
Since there were no anticoagulants, the only method to prevent clotting of the blood during collection was defibrination.
Experimental defibrination and bothropase: a study on the fibrinolytic mechanism in vivo.
Most of these species have venom that contains factors that can cause a consumption coagulopathy and defibrination, which may persist for days to weeks.
Generally, ACP is very effective at countering the defibrination syndrome that is often seen, but may do little for low platelet counts.
Other components found in the venom include a small basic peptide that works as a myotoxin, a fibrinogen-clotting enzyme that can produce defibrination syndrome, and a bradykinin-releasing enzyme.
Venous blood from healthy human volunteers aged between 18 and 70 was collected with EDTA or glass shot beads (Scientific Furnishings, Macclesfield, England) to remove platelets by defibrination.