clonal deletion

This negative selection is known as clonal deletion, one of the mechanisms for T cell tolerance.

In either case, the B cell is allowed to proliferate or is killed off through a process called clonal deletion.

Autoreactive T cells are eliminated in the thymus by a process of clonal deletion.

This antigen induced loss of cells from the B cell repertoire is known as clonal deletion.

When the B cell fails in any step of the maturation process, it will die by a mechanism called apoptosis, here called clonal deletion.

Clonal Deletion theory, proposed by Burnet, according to which self-reactive lymphoid cells are destroyed during the development of the immune system in an individual.

Anergy is one of three processes that induce tolerance induction, modifying the immune system to prevent self-destruction (the others being clonal deletion and immunoregulation).

Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones.

Clonal deletion is a process by which B cells and T cells are deactivated after they have expressed receptors for self-antigens and before they develop into fully immunocompetent lymphocytes.

When immature B cells express surface IgM that recognizes ubiquitous self-cell-surface (i.e. multivalent) antigens (such as those of the MHC) they are eliminated by a process known as clonal deletion.

This clonal deletion of T cells in the thymus cannot eliminate every potentially self-reactive T cell; T cells that recognize proteins only found at other sites in the body or only at certain times of development (e.g. after puberty) must be inactivated in the periphery.

I had to switch my immune system back into an immature state, temporarily, to make the transition work smoothly-I had to go through some of the childhood clonal deletion phases all over again, to weed out anything which might have caused an autoimmune response-but basically, I'm now able to shoot up pure HIV, and laugh about it."