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"It says sixty to one-hundred twenty-five grains would lead to bromism."
Bromism These are central nervous system reactions.
Bromism was once a very common disorder, being responsible for 5-10% of psychiatric hospital admissions.
Doses of 0.5-1 gram per day of bromide can lead to bromism.
Long-term use of potassium bromide (or any bromide salt) can lead to bromism.
Doses as low as 225 mg/day of LiBr can lead to bromism.
Eventually, bromism was diagnosed and hemodialysis was prescribed which resulted in a reversal of the disorder.
Bromism is caused by a neurotoxic effect on the brain which results in somnolence, psychosis, seizures and delirium.
Bromism is the syndrome which results from the long-term use of the bromide-based sedatives such as potassium bromide and lithium bromide.
The therapeutic dose of bromide is about 3-5 grams of bromide, thus explaining why chronic toxicity (bromism) was once so common.
While significant and sometimes serious disturbances occur to neurologic, psychiatric, dermatological, and gastrointestinal functions, death is rare from bromism.
I don't know whether Pepsi pours bromine into their drinks, but just in case they do let me mention the connection of Bromism and Cola:
Horowitz, B., "Bromism from Excessive Cola Consumption," Clinical Toxicology, 35(3), 1997, pp.
Bromism is diagnosed by checking the serum chloride level, electrolytes, glucose, BUN and creatinine, as well as symptoms such as psychosis.
The mechanism of bromism is due to high levels of bromide chronically impairing the membrane of neurons which progressively impairs neuronal transmission which leads to toxicity.
However, his condition resembled bromism, a semi-imbecile condition with slurred speech and drooling mouth. . . . "Bromism?"
Respiratory alkalosis Metabolic acidosis due to GI bicarbonate loss Bromism (excess intake of bromide, usually with sub-standard anticonvulsants) Excess infusion of normal saline Carbonic anhydrase inhibitors Renal tubular acidosis Lower-than-normal levels may indicate: