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The arachidonic acid cascade proceeds somewhat differently in the brain.
They are significant lipid mediators of the arachidonic acid cascade converted by 5-lipoxigenase.
Eicosanoids act as neurotransmitters via the Arachidonic acid cascade.
The arachidonic acid cascade in the central nervous system (CNS)
Many of the anti-mania medications used to treat bipolar disorder work by targeting the arachidonic acid cascade in the brain.
In the inflammatory response, two other groups of dietary fatty acids form cascades that parallel and compete with the arachidonic acid cascade.
One possible downstream target of several mood stabilizers such as lithium, valproate, and carbamazepine is the arachidonic acid cascade.
The production of these derivatives and their action in the body are collectively known as the "arachidonic acid cascade"; see essential fatty acid interactions for more details.
The mechanism of action of the flavonoids is based on the inhibition of enzymatic steps in the arachidonic acid cascade [ 38 ] .
Loschen G, Ebeling L. [Inhibition of arachidonic acid cascade by extract of rye pollen].
The disorder is caused by an anomaly in the arachidonic acid cascade, which causes increased production of cysteinyl leukotrienes, a series of chemicals involved in the body's inflammatory response.
In the arachidonic acid cascade, dietary linoleic acid (18:2 ω-6) is desaturated and lengthened to form arachidonic acid, esterified into the phospholipid fats in the cell membrane.
Cellular synthesis occurs through the arachidonic acid cascade with the final conversion from prostaglandin H2 (PGH) done by Prostaglandin D2 synthase (PTGDS).
It sits at the head of the "arachidonic acid cascade" - more than 20 different signalling paths that control a wide array of bodily functions, but especially those functions involving inflammation and the central nervous system.
PGE2 is an immunomodulatory eicosanoid derived from the cell membrane component, arachidonic acid, and is processed in the arachidonic acid cascade: the successive oxygenation and isomerization of arachidonic acid by cyclooxygenase and PGE2 synthase enzymes.