aminopterin

In the United States, aminopterin is licensed only for medical research like cancer treatment.

But regulators have never been able to confirm that aminopterin was present in contaminated pet food.

Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s.

Before the aminopterin was identified, officials had been focusing on wheat gluten as a source of the toxin.

Leucovorin has been used in rats, dogs and humans to rescue aminopterin toxicity.

Farber was able to use a drug of this type, aminopterin, to achieve a temporary remission in childhood leukemia.

These same reports stated that the FDA had failed to find evidence of aminopterin in the wheat gluten.

"We are confident we found aminopterin, and it makes sense with the pathology," Ms. Chittenden added.

Often the de novo pathway is interrupted as a result of chemotherapy drugs such as methotrexate or aminopterin.

Yellapragada Subbarao, known for the synthesis of the first ever chemotherapeutic drug aminopterin,subsequently synthesized methotrexate.

In the last days of the year, Farber injected his patient with an experimental drug, aminopterin, and within two weeks he was walking, talking and eating again.

After the tests, the company notified the College of Veterinary Medicine at Cornell University, which also did not find the aminopterin.

But F.D.A. officials said they had been unable to find aminopterin in the pet food samples they had tested.

The selective culture medium is called HAT medium because it contains hypoxanthine, aminopterin, and thymidine.

The New York State Food Laboratory reported that aminopterin was found in samples sent to them by Cornell.

Bob Rosenberg, senior vice president for government affairs at the National Pest Management Association, said that yesterday was the first he had heard of aminopterin.

Aminopterin (4-aminopteroic acid), a 4-amino analog of folic acid, is an antineoplastic drug with immunosuppressive properties used in chemotherapy.

Similar congenital abnormalities have been documented with methotrexate, and collectively their teratogenic effects have become known as the fetal aminopterin syndrome.

When a similar cluster of abnormalies appears in the absence of exposure to antifolates it is referred to as aminopterin-like syndrome without aminopterin.

This medium is supplemented with hypoxanthine, aminopterin and thymidine, hence the name HAT medium.

The method of selecting hybridomas is by use of HAT medium, which contain hypoxanthine, aminopterin, and thymidine.

Antimetabolite aminopterin blocks the cellular biosynthesis of purines and pyrimidines from simple sugars and amino acids.

One such medium that is commonly used is HAT medium, which contains hypoxanthine, aminopterin and thymidine.

It's too early to know for certain, but it seems very likely that tainted gluten slipped past quality inspections because aminopterin is not included in routine toxicity screens.

The use of aminopterin in cancer treatment was supplanted in the 1950s by methotrexate due to the latter's better therapeutic index in a rodent tumor model.