aminolysis

Alcoholysis and aminolysis are basically the reverse reactions of the cyclizations.

It's produced by the aqueous aminolysis of 3-cyanopyridine (nicotinonitrile) and subsequent crystallization.

In a recent example, Sandri and co-workers have used Taft plots in studies of polar effects in the aminolysis of β-lactams.

The formation of a covalent bond between penicillins and HSA as a result of aminolysis with lysine residues is believed to be involved in penicillin allergies.

In this process the racemic lactone reacts in aminolysis with (S)-methylbenzylamine assisted by triethylaluminum to a diastereomeric pair of amides which can be separated by column chromatography.

Another example of polyimides is the polyglutarimide typically made from polymethylmethacrylate (PMMA) and ammonia or a primary amine by aminolysis and cyclization of the PMMA at high temperature and pressure, typically in an extruder.