Treatment with lithium salts has been used as lithium improves uric acid solubility.

Hence the citric acid solubility of phosphate rocks has emerged as a measure of plant availability and enabled so-called 'reactive' phosphate rocks to be used as fertilizer minerals.

Raising the urinary pH to a level higher than 7 (alkalinization) is often difficult to attain, although sodium bicarbonate and/or acetazolamide are sometimes used in an attempt to increase uric acid solubility.