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He discovered Schiff bases and other imines, and was responsible for research into aldehydes and had the Schiff test named after him.
According to historical analysis of L. S. Ettre, however, Runge's work had "nothing to do with chromatography" (and instead should be considered a precursor of chemical spot tests such as the Schiff test).
The Schiff test is an early organic chemistry name reaction developed by Hugo Schiff, and is relatively general chemical test for detection of many organic aldehydes that has also found use in the staining of biological tissues.