N-cadherin

Currently it is believed that N-cadherin plays a role in the myelination process.

N-cadherin is critical to holding neural plate cells together.

Experimentation has shown that N-cadherin plays an important role in producing a remyelination-facilitating environment.

Mesenchymal cells usually express other cadherin types such as N-cadherin.

Fibronectin and N-cadherin are key to epithelialization in the developing embryo.

For example, cells containing N-cadherin tend to cluster with other N-cadherin-expressing cells.

Important molecules in these intercellular connections include N-cadherin, fibronectin, connexin and various integrins.

These cells are held together by cadherins (specifically E and N-cadherin), types of intercellular binding protein.

The transmembrane protein N-cadherin is often used as an indicator of in-vivo-like tissue assembly in 3D culturing.

A mouse mutant for N-cadherin suffers inflammatory bowel disease conditions and adenomas but does not develop carcinomas.

For example, the expression of N-cadherin is crucial to maintaining separation of precursor neural cells from precursor epithelial cells.

During the next stage, the development of the neural plate, N-cadherin (neural cadherin) is expressed and there is a decrease in E-cadherin.

A cell adhesion molecule known as neural cadherin (N-cadherin) is expressed predominantly in the nervous system, where it is implicated in neuronal migration during development.

Epithelial cells express high levels of E-cadherin, whereas mesenchymal cells express those of N-cadherin, fibronectin and vimentin.

The neural plate switches from E-cadherin expression to N-cadherin and N-CAM expression to recognize each other as the same tissue and close the tube.

Overexpression of an N-cadherin mutant incapable of adhesion prevents spine head expansion, demonstrating N-cadherin's essential role in this process.

The remaining somitomeres, likely driven by periodic expression of the hairy gene, begin expressing adhesion proteins such as N-cadherin and fibronectin, compact, and bud off forming somites.

In cultures of transfected MDCS cells, T-cadherin was also expressed apically, whereas N-cadherin located basolaterally corresponded to the zone of сеll contacts.

Additionally, mesenchymal-associated genes such as Snail, Slug, Zeb 1, 2, and N-cadherin were downregulated within the first 5 days post-OKSM induction.

In regenerating neural cells, neurite promoting factors play a role in adhesion of the axon and include neural cell adhesion molecule (N-CAM) and N-cadherin.

Thus, when the neural tube precursor cells begin expressing N-cadherin in the place of E-cadherin, this causes the neural tube to form and separate from the ectoderm and settle inside the embryo.

Only cells expressing the same kind of cadherin can bind to each other; since the peaks of the neural folds both express N-cadherin, they are able to merge into a continuous sheet of cells.

A characteristic of EMT is loss of the epithelial markers (E-cadherin, cytokeratins, claudin, occluding, desmoglein, desmocolin) and gain of mesenchymal markers (N-cadherin, vimentin, fibronectin) .

Glutamate binding to NMDA upregulates the production of N-cadherin's intracellular domain peptide, N-cad/CTF2, an effect blocked by the NMDA receptor antagonist, APV.

ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.