MHC antigen

Aberrant MHC antigens in a sarcoma virus-induced mouse tumour.

The HLA-A gene was discovered after a long process of determining MHC antigens.

Molecular Biology and Evolution of Blood Group and MHC antigens in Primates.

They observed that T-cell receptors must recognise a complex of foreign antigen and an MHC antigen in order to destroy infected cells.

Normal body cells are not recognized and attacked by NK cells because they express intact self MHC antigens.

Within the first week following the injury, microglia begin to proliferate abnormally and while doing so exhibit several immunophenotypic changes, particularly an increased expression of MHC antigens.

Those MHC antigens are recognized by killer cell immunoglobulin receptors (KIR) which essentially put the breaks on NK cells.

Associations described include those with C4 null allele, factor B Bf alleles, MHC antigens and IgA isotypes.

In humans and other vertebrates, the immune system uses MHC antigens to differentiate between "self" and "non-self" cells because these antigens are different from person to person.

Human lymphocyte bearing 1a-like antigens [now termed HLA-DK or class 1 MHC antigen]: Absence in patients with infantile Hypogammaglobulinemia.

Thus the requirement for mesenchyme seems to be associated with the early stages of thymopoiesis, whereas epithelial cells alone can support the later developmental stages, including those dependent on TCR-mediated interactions with MHC antigens in the thymic stroma.

Key determinants of metastatic behaviour include production growth and tumour angiogenesis factors; modulation of cell surface receptors and adhesion molecules; secretion of enzymes such as collagenase and plasminogen activator, and changes in the expression of MHC antigens.