J chain

Pentameric IgM can also be made in the absence of J chain.

It is a fully human pentameric IgM antibody with a mouse J chain.

IgM is primarily found in serum; however, because of the J chain, it is also important as a secretory immunoglobulin.

A J chain is a protein component of the antibodies IgM and IgA.

Immunoglobulin J chain is a protein that in humans is encoded by the IGJ gene.

The J Chain is required for IgM or IgA to be secreted into mucosa.

The J chain is found in pentameric IgM but not in the hexameric form, perhaps due to space constraints in the hexameric complex.

Because IgM and IgA are the only two types of antibody that polymerize, initial hypotheses stated that J chain was required for polymerization.

In other words, the first step of recombination for the light chains involves the joining of the V and J chains to give a VJ complex before the addition of the constant chain gene during primary transcription.

As part of the deal, both the Pilot and Flying J chains will keep their identities intact, while both chains started accepting the Comdata and Flying J's in-house TCH fuel cards.

'I am pleased and excited that the Office of Communication's long track record for media advocacy is being recognised by such a celebrated educational institution, even though we are only doing what the Gospels tell us to do,' said the Office's Director, Dr Beverly J Chain.

However, it was subsequently found that IgM is able to polymerize in the absence of J chain as both a pentamer and a hexamer, however, both of these exist to lesser numbers in organisms lacking J chains.

At present, it is still uncertain what fraction of normal pentamer contains J chain, and to this extent it is also uncertain whether a J chain-containing pentamer contains one or more than one J chain.